Extended Spectrum Beta Lactamases Producing Pseudomonas aeruginosa Expressing Amp C Beta-Lactamase Enzyme

This study determined the presence of Amp C beta lactamase producing Pseudomonas aeruginosa among the seventy four uropathogens studied using standard techniques. Results obtained revealed that the studied isolates show an alarming rate of resistance to the extended spectrum beta lactam antibiotics and the penicillin derivatives tested. The combination of piperacillin and tazobactam was however found to exert reasonable antibacterial activity as reflected in their relatively higher percentage susceptibility pattern (77%). 62.2% of the isolates were also sensitive to gentamicin. Of the 74 Pseudomonas aeruginosa tested in this study, 30 were Amp C Beta lactamase producers, 7 and 23 produced inducible and non inducible Amp C beta lactamases respectively. Five of the 30 Amp C beta lactamases producers produced extended spectrum beta lactamases while 21 of the these isolates produced metallo beta lactamase enzymes in addition to the Amp C enzymes. In conclusion, it can be said that there is an upsurge of Amp C beta lactamase producing Pseudomonas aeruginosa and treatment should only be commenced only prior to knowing the sensitivity pattern of Amp C isolates